A landmark research has recognized 5 sorts of micro organism related to aggressive prostate most cancers. It is unclear at this stage whether or not the micro organism is straight inflicting the most cancers however the researchers are assured they will develop new exams to establish aggressive prostate most cancers by monitoring the presence of those micro organism.
“We already know of some sturdy associations between infections and most cancers,” defined Colin Cooper, lead researcher on the venture. “For example, the presence of Helicobacter pylori bacteria in the digestive tract can lead to stomach ulcers and is associated with stomach cancer, and some types of the HPV virus can cause cervical cancer. We wanted to find out whether bacteria could be linked to the way prostate cancer grows and spreads.”
To investigate the relationship between bacteria and prostate cancer the researchers gathered prostate tissue and urine samples from more than 600 men. A variety of methods were deployed to detect bacteria in the samples, from whole genome DNA sequencing to anaerobic culture and fluorescent microscopy.
Five types of bacteria were ultimately found to be associated with the most aggressive forms of prostate cancer, three of those were entirely new species. The presence of one or more of these bacteria could be linked with more rapid progression of disease.
Rachel Hurst, first author on the new study, stressed it is still early days for the research and the findings raise plenty of novel questions. Even if the link between these bacteria and prostate cancer is verified in future studies it isn’t yet understood if the relationship is causal.
“We also identified potential biological mechanisms of how these bacteria may be linked to cancer,” famous Hurst. “Among the issues we do not but know is how folks choose up these micro organism, whether or not they’re inflicting the most cancers, or whether or not a poor immune response permits the expansion of the micro organism.”
Perhaps essentially the most speedy end result from the findings might be a possible diagnostic take a look at to assist medical doctors and sufferers establish aggressive prostate most cancers earlier than it develops. Co-author Daniel Brewer mentioned it’s doable to supply a fast and simple take a look at to detect these micro organism that might higher information remedy choices.
“Knowing when we can watch and wait or whether we need to start treatment is a major challenge for people with prostate cancer,” said Brewer. “If we can target aggressive cancers while sparing others from unnecessary treatment it will dramatically improve the way we manage this disease.”
Beyond a new diagnostic test the most exciting prospect coming out of this study is the possibility these bacteria directly play a role in causing prostate cancer. The researchers suggest it is likely the microbes play some kind of role in either triggering the development of cancer or speeding up tumor growth.
A number of hypotheses are raised to explain how the bacteria could be causing prostate cancer but it’s all incredibly speculative at this point. Now that a clear association has been reported the real work to explore potential causal mechanisms can begin.
Hayley Luxton, from Prostate Cancer UK, said the implications of finding a bacterial cause for prostate cancer would be enormous. Speaking to The Guardian, Luxton said the research could “revolutionize” prostate cancer treatment.
“If the team can demonstrate that these newly identified bacteria can not only predict, but actually cause aggressive prostate cancer, for the first time we may actually be able to prevent prostate cancer occurring,” said Luxton. “This would be a huge breakthrough that could save thousands of lives each year.”
The new study was published in the journal European Urology Oncology.
Source: University of East Anglia